Abstract：Objective：To observe the effect of the therapy of Dachaihu tang combined with Dachengqi tang and routine western medicine on intestinal mucosal barrier function in patients with acute pancreatitis(AP). Methods ： A total of 62 patients with AP were selected and divided into the control group and the experiment group according to the random number table method，with 30 and 32 cases in each group respectively. The control group was treated with routine western medicine，and the experiment group was additionally treated with Dachengqi tang combined with Dachaihu tang based on the treatment of the control group. Both groups were treated for one course， 10 days being a course. The clinical effects and adverse reactions in the two groups were observed. The improvement time of abdominal pain and distension and the recovery time of fart and defecation were compared. Before and after treatment， the changes of C- reactive protein(CRP)， serum interleukin-8(IL-8) and serum interleukin-6(IL-6) in the two groups were compared. Results：After treatment，the recovery time of fart and defecation and the improvement time of abdominal pain and distension in the experiment group were shorter than those in the control group，differences being significant(P＜0.05). After treatment，the levels of CRP，IL-6 and IL-8 in the two groups were decreased when compared with those before treatment and the above three levels in the experiment group were lower than those in the control group，differences being significant(P＜0.05). The total clinical effective rate was 87.50% in the experiment group，and 73.33% in the control group，there being no significance in the difference(P＞0.05). During treatment，no adverse reactions occurred in both groups. Conclusion：The therapy of Dachaihu tang combined with Dachengqi tang and routine western medicine for AP can significantly reduce the abdominal pain， promote the fart and defecation，and effectively protect the intestinal mucosal barrier function，with high administration safety.