Abstract： Objective： To observe the clinical effect of the therapy of Weifuchun tablets assisting routine western medicine on senile chronic atrophic gastritis(CAG) and its effect on inflammatory factors. Methods： A total of 164 cases of clinical data of elderly patients with CAG were retrospectively selected and divided into the control group and the observation group according to the treatment methods， with 82 cases in each group. The control group was treated with oral administration of cinitapride hydrogen tartrate tablets， and the observation group was additionally treated with Weifuchun tablets based on the treatment of the control group. Before and after treatment，the symptom scores，inflammatory factors， including interleukin- 6(IL- 6)， tumor necrosis factor- α(TNF- α) and interleukin- 8(IL- 8)， and oxidative stress indicators， including nitric oxide(NO) and superoxide dismutase(SOD)， in the two groups were compared. The clinical effects and incidences of adverse reactions were statistically analyzed. Results：The total effective rate was 97.56% in the observation group， higher than that of 87.80% in the control group， the difference being significant(P＜0.05). After treatment， the scores of fatigue，dull pain，stomach cavity fullness and poor appetite in the two groups were decreased when compared with those before treatment，and the above scores in the observation group were lower than those in the control group，the difference being significant(P＜0.05). After treatment，the levels of IL-6，TNF-α and IL-8 in the two groups were decreased when compared with those before treatment，and the above levels in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of NO and SOD in the two groups were increased when compared with those before treatment，and the above levels in the observation group were higher than those in the control group， the difference being significant(P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(χ 2=2.939， P=0.086). Conclusion： The therapy of Weifuchun tablets assisting routine western medicine for senile CAG has a definite effect，which can improve the symptoms and oxidative stress level，and reduce the inflammatory responses，with few adverse reactions.