Abstract：Objective：To observe the clinical effect of the additional application of Bushen Jianpi Dizhuo tang based on routine therapy for stage 3 of chronic kidney disease with spleen- kidney yang deficiency syndrome. Methods： A total of 112 cases of patients with stage 3 of chronic kidney disease with spleen-kidney yang deficiency syndrome were divided into the control group and the treatment group according to the random number table method，with 56 cases in each group. Both groups were given routine treatment in modern medicine， and the observation group was additionally given oral administration of Bushen Jianpi Dizhuo tang. Both groups were treated for three months. Before and after treatment， the changes in 24-hour urinary protein excretion(24hU-Pro)，kidney function including serum creatinine(SCr)，blood urea nitrogen (BUN) and cystatin C(CysC)， main symptoms of spleen- kidney yang deficiency syndrome and levels of fibrinogen and Ddimer in plasma in the two groups were observed. The clinical effects in the two groups were compared. Results： After three- month treatment， the total effective rate of clinical effect was 80.36% in the observation group and 62.50% in the control group， the difference being significant(P＜0.05). The levels of BUN， SCr， 24hU- Pro and CysC in the two groups were decreased when compared with those before treatment， and the glomerular filtration rates were increased， differences being significant(P＜0.01). The levels of BUN， SCr， 24hU- Pro and CysC in the observation group were lower than those in the control group， and the glomerular filtration rate was higher， differences being significant(P＜0.01). The scores of main symptoms of spleen- kidney yang deficiency syndrome in the two groups were decreased when compared with those before treatment(P＜0.01)，and the score in the observation group was lower than that in the control group(P＜ 0.01). The levels of fibrinogen and D-dimer in the two groups were decreased when compared with those before treatment (P＜0.01)，and the levels in the observation group were lower than those in the control group(P＜0.01). Conclusion：Based on routine treatment， the additional application of Bushen Jianpi Dizhuo tang for stage 3 of chronic kidney disease with spleen- kidney yang deficiency syndrome can improve kidney function，coagulation function and clinical effect，and relieve symptoms.