Abstract： Objective： To observe the clinical effect of Fuzi Lizhong pills for salivation after taking clozapine in schizophrenia. Methods：A total of 45 cases of schizophrenia patients with salivation after taking clozapine only were selected as the study subjects and randomly divided into two groups according to enrollment order. The control group(22 cases) was treated with propantheline bromide tablets，and the treatment group(23 cases) were treated with Fuzi Lizhong pills combined with propantheline bromide tablets. Clinical effects and adverse reactions were compared between the two groups. Chinese medicine syndrome scores， scores of severe degree of salivation and levels of serum cholinesterase were compared between the two groups before treatment， after one- week treatment and after two- week treatment. Results： The total clinical effective rate was 86.96% in the treatment group，higher than that of 59.09% in the control group(P＜0.05). When compared with those before treatment，Chinese medicine syndrome scores of short breath and lack of strength，lassitude of spirit and somnolence，poor appetite，spontaneous sweating and dyspnea，and salivation as well as scores of salivation in Rating Scale For Extrapyramdal Side Effects(RSESE) and the severe degree of salivation in the two groups were decreased after one- week and two- week treatment(P＜0.05)， and levels of serum cholinesterase were increased(P＜0.05). When compared with those in the control group after one-week and two-week treatment，Chinese medicine syndrome scores of short breath and lack of strength，lassitude of spirit and somnolence，poor appetite，spontaneous sweating and dyspnea， and salivation as well as scores of salivation in RSESE and the severe degree of salivation in the treatment group at the same period were lower(P＜0.05)， and level of serum cholinesterase was higher(P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P＞0.05). Conclusion：Fuzi Lizhong pills combined with propantheline bromide tablets can improve clinical symptoms of schizophrenia patients with salivation after taking clozapine，and enhance level of serum cholinesterase and clinical effect.