Abstract： Objective： To observe the clinical effect of the therapy of modified Sijunzi tang combined with conventional western medicine on the treatment of chronic atrophic gastritis with spleen-stomach weakness syndrome. Methods：A total of 120 patients with chronic atrophic gastritis with spleen-stomach weakness syndrome were selected and divided into the observation group and the control group according to random number table method，with 60 cases in each group. The control group was treated with conventional western medicine， and the observation group was additionally treated with modified Sijunzi tang based on the treatment of the control group. The clinical effects，Chinese medicine syndrome scores，gastric mucosal pathology and levels of inflammatory factors were compared between the two groups. Results：The total effective rate in the observation group was better than that in the control group(χ 2=5.551， P=0.018). After treatment， scores of Chinese medicine symptoms in both groups were decreased when compared with those before treatment(P＜0.05)； the scores of Chinese medicine symptoms in the observation group were lower than those in the control group(P＜0.05). After treatment， the degree of gastric gland atrophy and intestinal metaplasia in the two groups was significantly relieved when compared with that before treatment(P＜0.05)， and the above degree in the observation group was less than that in the control group(P＜0.05). After treatment， the levels of human epidermal growth factor(EGF) and interleukin- 32(IL- 32) in serum in both groups were decreased when compared with those before treatment，and the levels of calcitonin gene-related peptide(CGRP) were increased(P＜0.05). After treatment，the levels of EGF and IL- 32 in the observation group were lower than those in the control group， and CGRP level was higher(P＜0.05). Conclusion： The therapy of modified Sijunzi tang combined with conventional western medicine is effective in the treatment of chronic atrophic gastritis with spleen-stomach weakness syndrome，which is beneficial to alleviating the clinical symptoms and inflammatory injury of gastric mucosa，and improving gastric mucosa tissue.