Abstract： Objective： To observe the clinical effect of the therapy of modified Buzhong Yiqi tang combined with fluconazole on candida albicans pneumonia. Methods：A total of 78 patients with candida albicans pneumonia were selected and divided into the observation group and the control group according to the random number table method，with 39 cases in each group. The control group was treated with fluconazole，and the observation group was additionally treated with modified Buzhong Yiqi tang based on the treatment of the control group. The clinical effects，symptom scores，levels of (1，3)-β-Dglucan and negative conversion rates of sputum fungal culture in the two groups were compared. Results：The total effective rate was 97.44% in the observation group，higher than that of 84.62% in the control group，the difference being significant (χ 2=3.924，P=0.048). After treatment，the scores of cough，wheezing and expectoration in the two groups were lower than those before treatment(P＜0.05)；after treatment，the above scores in the observation group were lower than those in the control group(P＜0.05). On the 3rd，7th，10th and 14th days during treatment，the levels of (1，3)-β-D-glucan in both groups showed a continuously decreasing trend when compared with those before treatment(P＜0.05)，and the above level at each time point in the observation group was lower than that in the control group respectively(P＜0.05). The negative conversion rate of sputum fungal culture was 89.74% in the observation group，higher than that of 71.79% in the control group，the difference being significant(χ 2=4.044， P=0.044). Conclusion： The therapy of modified Buzhong Yiqi tang combined with fluconazole has a remarkable effect on candida albicans pneumonia， which can effectively relieve the clinical symptoms， reduce the level of (1，3)-β-D-glucan，and improve the negative conversion rate of sputum fungal culture.