Abstract：Objective：To observe the curative effect of Wenxin granules combined with valsartan capsules for paroxysmal atrial fibrillation and its effect on heart function and levels of high-sensitivity C-reactive protein(hs-CRP). Methods：A total of 82 cases of patients with paroxysmal atrial fibrillation were retrospectively selected and divided into the control group and the observation group according to different treatment methods，with 41 cases in each group. The control group was given oral administration of valsartan capsules，and the observation group was additionally treated with Wenxin granules based on the treatment of the control group. The Chinese medicine syndrome scores， onset frequency and duration of atrial fibrillation， resting heart rate， heart function and hs- CRP before and after treatment and the clinical effects in the two groups were compared. The incidence of adverse reactions was observed. Results：The total effective rate was 92.68% in the observation group，higher than that of 75.61% in the control group，the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores of palpitation，chest discomfort，shortness of breath，tiredness and weakness，sweating，and red tongue and greasy coating in the two groups were decreased when compared with those before treatment， and the above scores in the observation group were lower than those in the control group(P＜0.05). After treatment，onset frequency and duration of atrial fibrillation and resting heart rates in the two groups were decreased when compared with those before treatment， and the above indexes in the observation group were lower than those in the control group(P＜0.05). After treatment， left ventricular end systolic dimension(LVESD)， left ventricular end diastolic diameter(LVEDD) and P- wave dispersion(Pd) in the two groups were decreased when compared with those before treatment，and left ventricular ejection fraction(LVEF) was increased(P＜0.05)；LVESD，LVEDD and Pd in the observation group were lower than those in the control group，and LVEF was higher(P＜0.05). After treatment，the levels of hs-CRP and N-terminal pro b-type natriuretic peptide (NT-proBNP) in the two groups were decreased when compared with those before treatment，and the levels of hs-CRP and NT-proBNP in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 4.88% in the observation group， lower than that of 19.51% in the control group， the difference being significant(P＜ 0.05). Conclusion：Wenxin granules combined with valsartan capsules has a significant curative effect in treating paroxysmal atrial fibrillation，which can improve clinical symptoms and heart function，reduce hs- CRP levels，control heart rates and onset frequency，and shorten duration of arrhythmia，with few adverse reactions.