Abstract：Objective：To observe the effects of the therapy of Shihu Yangwei tang combined with omeprazole entericsoluble capsules on inflammatory factors and levels of oxidative stress in patients with chronic atrophic gastritis with deficiency of stomach yin syndrome. Methods：A total of 80 cases with chronic atrophic gastritis with deficiency of stomach yin syndrome were selected and divided into the control group and the observation group according to random number table method， with 40 cases in each group. The control group was given omeprazole enteric- soluble capsules orally， and the observation group was given omeprazole enteric-soluble capsules combined with Shihu Yangwei tang. The treatment course of both groups was four weeks. The clinical effects in the two groups were compared，and the Chinese medicine syndrome scores， the levels of inflammatory factors including C- reactive protein(CRP) and interleukin- 6(IL- 6)， and oxidative stress factors including superoxide dismutase(SOD) and malondialdehyde(MDA) before and after treatment as well as the incidence of adverse reactions in the two groups were observed. Results：The total effective rate of clinical effect was 72.50% in the control group and 95.00% in the observation group，the difference being significant(P＜0.05). After treatment，the scores of Chinese medicine syndromes such as poor appetite， pain and distention in the stomach cavity and stabbing pain in the stomach in both groups were decreased when compared with those before treatment(P＜0.05). The scores in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the levels of CRP and IL- 6 in both groups were decreased when compared with those before treatment(P＜0.05)；and the two levels in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，the SOD levels were increased and MDA levels were decreased in both groups when compared with those before treatment， differences being significant(P＜0.05). After treatment， the SOD level in the observation group was higher than that in the control group， and the MDA level was lower， differences being significant(P＜0.05). During treatment， the incidence of adverse reactions in the control group was 12.50% and 5.00% in the observation group，there being no significant difference between the two groups(P＞0.05). Conclusion： The therapy of Shihu Yangwei tang combined with omeprazole entericsoluble capsules has a significant therapeutic effect on the treatment of chronic atrophic gastritis with deficiency of stomach yin syndrome，which can relieve the clinical symptoms and reduce the inflammatory responses of patients，with relatively great safety.