Abstract：Objective：To observe the clinical effect of plum-blossom needle tapping combined with Longdan Xiegan tang for postherpetic neuralgia， and its effect on β- endorphin(β- EP)， substance P(SP) and prostaglandin E2(PGE2) in serum. Methods：A total of 292 cases of patients with postherpetic neuralgia were selected as the study subjects，and divided into the control group and the observation group according to the random number table method，with 146 cases in each group. The control group was given oral administration of routine western medicine and Longdan Xiegan tang，and the observation group was additionally treated with plum- blossom needle tapping based on the treatment of the control group. The clinical effects，Visual Analogue Scale(VAS) scores，Quality of Life(QOL) scores，and levels of SP，PGE-2 and β-EP in serum in the two groups were compared. The condition of stopping vesiculation and forming scab in the two groups were observed. Results：The total effective rate was 97.26% in the observation group，higher than that of 79.45% in the control group，the difference being significant(χ 2=20.805，P＜0.05). After treatment，the VAS scores in the two groups were decreased when compared with those before treatment，and the VAS score in the observation group was lower than that in the control group (P＜0.05)；the QOL scores in the two groups were increased when compared with those before treatment，and the QOL score in the observation group was higher than that in the control group(P＜0.05). After treatment，the levels of SP and PGE-2 in serum in the two groups were decreased when compared with those before treatment，and the levels of SP and PGE-2 in serum in the observation group were lower than those in the control group(P＜0.05)；the levels of β- EP in serum in the two groups were increased when compared with those before treatment，and the level of β-EP in serum in the observation group was higher than that in the control group(P＜0.05). The time of stopping vesiculation and forming scab in the observation group was shorter than that in the control group(P＜0.05). Conclusion： Plum- blossom needle tapping combined with Longdan Xiegan tang for postherpetic neuralgia can effectively decrease levels of β-EP and PGE2 in serum，improve β-EP levels and quality of life，relieve pain and promote rehabilitation，with a significant curative effect.