Abstract：Objective：To observe the clinical effect of micro needle knife combined with exercise therapy for shoulder- hand syndrome after stroke. Methods： A total of 60 cases of patients with shoulder- hand syndrome after stroke were selected and divided into the observation group and the control group according to the random number table method，with 30 cases in each group. The control group was given simple exercise therapy，and the observation group was given micro needle knife combined with exercise therapy. Scores of shoulder joint motor function evaluated by simplified Fugl- Meyer Assessment(FMA)，Visual Analogue Scale(VAS) for pain evaluation，and activities of daily living evaluated by modified Barthel Index(MBI) were compared between the two groups before and after treatment. Clinical effects were evaluated. Results：The total effective rate was 93.33% in the observation group， higher than that of 70.00% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of scores of FMA，VAS，and MBI between the two groups(P＞0.05). After treatment，scores of FMA and MBI in the two groups were increased when compared with those before treatment，and VAS scores were decreased(P＜0.05). After treatment，scores of FMA and MBI in the observation group were higher than those in the control group，and VAS score was lower(P＜0.05). Conclusion：Micro needle knife combined with exercise therapy has a significant effect in the treatment of shoulder- hand syndrome after stroke， with characteristics of safety， efficiency， and simple operation. It can enhance activities of daily living and quality of life of patients，and promote rehabilitation.