Abstract：Objective：To analyze the administration rule of Chinese medicine in the gynecological outpatient department of Guangdong Hospital of Traditional Chinese Medicine in the treatment of menstrual headache based on data mining technology， and to provide reference for clinical treatment of such diseases. Methods： The authors searched the medical records of the gynecology outpatient department of Guangdong Hospital of Traditional Chinese Medicine from January 2020 to August 2021， screened the medical data for the treatment of menstrual headache， established the standardized medical case database with Excel 2019， and analyzed the frequency of herbal use， natures and flavours， common herbal combinations and core prescriptions of the collected medical cases through the functions of statistical analysis， correlation analysis， cluster analysis and complex network analysis in the Ancient and Modern Medical Cases Cloud Platform V2.3. Results：A total of 258 effective medical cases and 258 prescriptions were included，involving 214 kinds of Chinese herbs. According to the statistics，there were 20 kinds of Chinese herbs with high frequency (over 40 times of use)，and the top four were Radix Paeoniae Alba， Radix Bupleuri， Radix Angelicae Sinensis and Rhizoma Chuanxiong. The natures of herbs were mainly neutral， warm and mild cold； the flavours of herbs were mainly sweet， acrid and bitter. The herbs mainly entered into the liver，spleen，lung，kidney and heart channels. There were 18 association rules obtained from the analysis and five prescriptions obtained by cluster analysis. Conclusion：The treatment methods mainly used by the Chinese medicine practitioners in gynecological outpatient department of Guangdong Hospital of Traditional Chinese Medicine are the methods of supplementing blood and invigorating blood and moving qi to relieve pain. The core prescriptions consist of Radix Paeoniae Alba， Radix Angelicae Sinensis， Radix Bupleuri， Rhizoma Chuanxiong， Radix et Rhizoma Glycyrrhizae Praeparata cum Melle，Rhizoma Atractylodis Macrocephalae and Poria.