Abstract：Objective：To observe the curative effect of the therapy of Zhibai Dihuang pills combined with Wuling powder based on routine therapy on nephrotic syndrome(NS) of syndrome of liver- kidney yin deficiency complicated with waterdampness retention. Methods： A total of 68 patients with NS of syndrome of liver- kidney yin deficiency complicated with water- dampness retention were randomly divided into the control group and the observation group，with 34 cases in each group. Both groups were treated with routine basic therapy，such as immune support and high-quality protein supplement， and prednisone acetate tablets. The observation group was additionally treated with Zhibai Dihuang pills combined with Wuling powder. Both groups were treated for six months. The curative effects in the two groups were compared. Before and after treatment， the serum bone metabolism indexes， including bone gla protein(BGP)， intact parathyroid hormone(iPTH) and bone- specific alkaline phosphatase(BALP)， kidney function indexes， including urine β2- microglobulin(β2- MG) and α1- microglobulin(α1- MG)， and serum inflammatory indexes， including interleukin- 4(IL- 4) and interleukin- 6(IL- 6)， were compared. Results：After six months of treatment，the total clinical effective rate in the observation group was higher than that in the control group(P＜0.01). The serum BGP levels in both groups were increased when compared with those before treatment，and the serum levels of iPTH and BALP were decreased，differences being significant(P＜0.05). The serum BGP level in the observation group was higher than that in the control group，and the serum levels of iPTH and BALP were lower， differences being significant(P＜0.05). The levels of urine β2- MG and α1- MG in the two groups were decreased when compared with those before treatment(P＜0.05)，and the two levels in the observation group were lower than those in the control group(P＜0.05). The serum levels of IL- 4 and IL- 6 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above two levels in the observation group were lower than those in the control group(P＜ 0.05). Conclusion： Compared with western medicine treatment， the therapy of Zhibai Dihuang pills and Wuling powder based on routine therapy for patients with NS of syndrome of liver-kidney yin deficiency complicated with water-dampness rentention can more effectively reduce the inflammation，enhance the clinical effect，and improve the bone metabolism and kidney function.