Abstract：Objective：To observe the clinical effect of the therapy of Erhuang Jiedu tang combined with hydrocortisone on the treatment of sepsis complicated with gastrointestinal dysfunction of heat accumulation in the intestine type. Methods：A total of 66 patients with sepsis were selected and divided into the control group and the observation group according to random number table method， with 33 cases in each group. The two groups received treatment of conventional western medicine. The control group was treated with hydrocortisone；the observation group was additionally treated with Erhuang Jiedu tang based on the treatment of control group. The treatment course of both groups was one week. The scores of gastrointestinal dysfunction， abdominal pressure， scores of acute physiological and chronic health status(APACHE Ⅱ) and Marshall，and levels of serum hypersensitive C- reactive protein (hS- CRP) and procalcitonin(PCT) were compared between the two groups. Results：After treatment，the scores of gastrointestinal dysfunction and abdominal pressure in both groups were significantly decreased when compared with those before treatment(P＜0.01)， and the scores of gastrointestinal dysfunction and abdominal pressure in the observation group were significantly lower than those in the control group(P＜0.01). After treatment， the scores of APACHE Ⅱ and Marshall in both groups were significantly decreased when compared with those before treatment (P＜0.01)，and the above two scores in the observation group were significantly lower than those in the control group(P＜0.01). After treatment， the levels of serum hS- CRP and PCT in both groups were decreased when compared with those before treatment (P＜0.01)， and the above two indexes in the observation group were significantly lower than those in the control group (P＜0.01). Conclusion： Based on the conventional treatment， the application of Erhuang Jiedu tang combined with hydrocortisone sepsis complicated with gastrointestinal dysfunction of heat accumulation in the intestine syndrome can inhibit inflammatory for responses，effectively improve the gastrointestinal function of patients and alleviate their clinical symptoms.