Abstract： Objective： To observe the clinical effect of Qingyi prescription combined with Shenmai injection for severe acute pancreatitis(SAP). Methods： A total of 100 cases of SAP patients were divided into the observation group and the control group according to their different treatment methods，with 50 cases in each group. Both groups were given routine treatment， the control group was additionally treated with Shenmai injection， and the observation group was additionally treated with Qingyi prescription based on the treatment of the control group. Both groups were treated for two weeks. The clinical effects and the remission duration of symptoms in the two groups were compared. Before and after treatment，the levels of blood amylase，urine amylase，inflammatory factors and the indexes of immune function in the two groups were compared. Results：The total effective rate was 90.00% in the observation group，higher than that of 78.00% in the control group(P＜0.05). The remission duration of abdominal pain，the recovery time of bowel sounds，the first defecation time and the recovery time of blood amylase in the observation group were shorter than those in the control group(P＜0.05). After treatment， the levels of blood amylase and urine amylase in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of blood amylase and urine amylase in the observation group were lower than those in the control group(P＜0.05). After treatment，CD4 + levels and CD4 +/CD8 + values in the two groups were increased when compared with those before treatment(P＜0.05)，and CD8+ levels were decreased(P＜0.05)；CD4+ level and CD4+/CD8+ value in the observation group were higher than those in the control group(P＜0.05)，and CD8+ was lower(P＜0.05). After treatment， the levels of high- sensitivity C- reactive protein(hs- CRP)， interleukin- 2(IL- 2)， interleukin- 6(IL- 6) and tumor necrosis factor-α(TNF-α) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of hs-CRP，IL-2，IL-6 and TNF-α in the observation group were lower than those in the control group(P＜0.05). Conclusion： Qingyi prescription combined with Shenmai injection has a good clinical effect in treating SAP， can improve immune function，reduce levels of inflammatory factors and relieve clinical symptoms.