Abstract： Objective： To observe the clinical effect of Qingxia Huayu prescription combined with early enteral nutrition support for severe acute pancreatitis(SAP)， and its effect on intestinal mucosal barrier function and immune function of patients. Methods：A total of 90 cases of SAP patients were selected and divided into the observation group and the control group according to the random number table method，with 45 cases in each group. Both groups were given routine treatment such as fasting and gastrointestinal decompression； the control group was additionally treated with early enteral nutrition support，and the observation group was additionally treated with Qingxia Huayu prescription based on the treatment of the control group. Both groups were treated for 14 days. The indexes of intestinal mucosal barrier function including endotoxin and diamine oxidase， immunoglobulin(Ig) and Chinese medicine syndrome scores before and after treatment as well as the clinical effects in the two groups were compared；the adverse reactions were observed. Results：The total effective rate was 88.89% in the observation group，higher than that of 71.11% in the control group(P＜0.05). After treatment，the levels of endotoxin and diamine oxidase in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of endotoxin and diamine oxidase in the observation group were lower than those in the control group(P＜ 0.05)；the levels of IgA，IgG and IgM in the two groups were increased when compared with those before treatment(P＜ 0.05)，and the levels of IgA，IgG and IgM in the observation group were higher than those in the control group(P＜0.05). After treatment，the scores of primary and secondary symptoms in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of primary and secondary symptoms in the observation group were lower than those in the control group(P＜0.05). During treatment，there was no serious adverse reaction in the two groups. Conclusion： The therapy of Qingxia Huayu prescription combined with early enteral nutrition support for SAP can improve the intestinal mucosal barrier function and immune function of patients，relieve their clinical symptoms and enhance the clinical effect.