Abstract： Objective： To study the anti- inflammatory， analgesic and antipyretic effects of Qingzhuo Qudu pills. Methods： The anti- inflammatory effect of Qingzhuo Qudu pills was observed by xylene induced ear swelling in mice and carrageenan induced foot swelling in rats. The analgesic effect was observed by hot plate method and acetic acid writhing method. The antipyretic effect was studied by dry yeast induced fever model in rats. Results： The results of antiinflammatory experiment showed that compared with the control group，the ear swelling of mice and foot swelling of rats in Qingzhuo Qudu pills group were significantly reduced(P＜0.05). The results of analgesic experiment showed that the latency and pain threshold of pain response in mice treated with Qingzhuo Qudu pills were significantly increased compared with those in the control group(P＜0.05， P＜0.01). The results of antipyretic experiment showed that compared with the model group， the body temperature of rats in Qingzhuo Qudu pills group decreased significantly(P＜0.01). Conclusion： Qingzhuo Qudu pills has good anti-inflammatory，analgesic and antipyretic effects.