Abstract：Objective：To observe the clinical effect of combined application of ossotide injection combined with Danhong injection for patients after osteoporotic fracture surgery. Methods：A total of 128 cases of patients with osteoporotic fracture were selected and divided into the control group and the observation group according to the random number table method， with 64 cases in each group. Both groups were given surgery. The control group was treated with routine medicine，and the observation group was additionally treated with ossotide injection combined with Danhong injection based on the treatment of the control group. Clinical effects were compared between the two groups. Before and after treatment， changes in bone metabolism [serum type I carboxy-terminal collagen crosslinks(CTX-1)，bone alkaline phosphatase(BALP)，bone gla protein (BGP)] and coagulation function [thrombin time(TT)，prothrombin time(PT)，activated partial thromboplastin time(APTT)] were compared between the two groups. Incidences of adverse reactions during treatment were observed in the two groups. Results：The total clinical effective rate was 90.63% in the observation group and 75.00% in the control group，the difference being significant(P＜0.05). After treatment， CTX- 1 levels in the two groups were decreased when compared with those before treatment， and levels of BALP and BGP were increased， differences being significant(P＜0.05). After treatment， CTX- 1 level in the observation group was lower than that in the control group，and levels of BALP and BGP were higher， differences being significant(P＜0.05). After treatment，levels of TT，PT and APTT in the two groups were increased when compared with those before treatment，and the above three levels in the observation group were higher than those in the control group，differences being significant(P＜0.05). The incidence of adverse reactions was 9.38% in the observation group and 10.94% in the control group， there being no significance in the difference(P＜0.05). Conclusion： Ossotide injection combined with Danhong injection has a good curative effect in the treatment of osteoporotic fracture，which can effectively improve bone metabolism and coagulation function，and promote the healing from fracture，with relatively high safety.