Abstract：Objective：To observe the clinical effect of azithromycin granules combined with Xiao'er Xiaoji Zhike oral liquid for mycoplasma pneumonia complicated with geographic tongue. Methods：A total of 405 cases of children with mycoplasma pneumonia complicated with geographic tongue were retrospectively analyzed and divided into the treatment group and the control group according to different treatment schemes. The control group was treated with routine symptomatic treatment and azithromycin granules，and the treatment group was additionally treated with Xiao'er Xiaoji Zhike oral liquid based on the treatment of the control group. Chinese medicine syndrome scores， Pneumonia symptom scores， geographic tongue symptom scores，as well as specific antibody contents of immunoglobulin(IgM) and immunoglobulin A(IGA) in serum in the two groups were observed before and after treatment，and the clinical effects and adverse reactions in the two groups were evaluated. Results： The curative effect in the treatment group was better than that in the control group(P＜0.05). After treatment，Chinese medicine syndrome scores，each score of pneumonia，geographic tongue symptom scores in the two groups were decreased(P＜0.05)，and the scores in the treatment group were lower than those in the control group(P＜0.05). After treatment， contents of IgM and IgA in serum in the two groups were decreased(P＜0.05)， and the contents in the treatment group were lower than those in the control group(P＜0.05). There was no significant difference being found in the comparison of the incidience of adverse reactions between the two groups(P＜0.05). Conclusion： Azithromycin granules combined with Xiao'er Xiaoji Zhike oral liquid has a relatively good curative effect on mycoplasma pneumonia complicated with geographic tongue，which can significantly relieve asthma，cough and geographic tongue symptoms，and improve humoral immune function，with good safety.