Abstract： Objective： To explore and analyze the medication rules of Professor LI Qixin in the treatment of erectile dysfunction based on Chinese medicine inheritance support system V2.5. Methods：Medical records related to patients with erectile dysfunction treated by Professor LI Qixin were collected and sorted out， and a total of 112 prescriptions were screened out and recorded into Chinese medicine inheritance support system V2.5. Integration rule analysis， unsupervised entropy hierarchical clustering，improved mutual information method，complex system entropy clustering，analysis of four qi，five flavors and meridian entry and other methods of the software were used to analyze and excavate the medication rules of Professor LI Qixin in the treatment of erectile dysfunction. Results： A total of 29 medicines were used for more than 20 times，and the top 10 medicines were Herba Epimedii，Radix Bupleuri，Fructus Tribuli，Radix et Rhizoma Glycyrrhizae， Radix Paeoniae Alba， Fructus Lycii， Radix Astragali， Herba Cynomorii， Radix et Rhizoma Salviae Miltiorrhizae and Poria. Association rule analysis with support degree of 20 and confidence degree of 0.6 showed that the top 10 combinations were Herba Epimedii- Radix Bupleuri， Herba Epimedii- Fructus Tribuli， Radix Bupleuri- Fructus Tribuli， Herba Epimedii- Radix Paeoniae Alba，Herba Epimedii-Fructus Lycii，Radix Paeoniae Alba-Radix Bupleuri，Radix et Rhizoma Glycyrrhizae-Herba Epimedii， Radix et Rhizoma Glycyrrhizae- Radix Bupleuri， Radix et Rhizoma Glycyrrhizae- Radix Paeoniae Alba and Herba Epimedii- Radix Bupleuri- Fructus Tribuli. Based on the analysis of complex system entropy clustering， the core medicine combinations were Radix et Rhizoma Glycyrrhizae Praeparata cum Melle- Radix et Rhizoma Glycyrrhizae- Fructus Corni and Fructus Lycii- Semen Coicis- Semen Vaccariae. Based on the analysis of unsupervised entropy hierarchical clustering， two new prescriptions were obtained， namely， Radix Paeoniae Alba- Radix et Rhizoma Glycyrrhizae- Fructus Corni- Radix Puerariae Lobatae and Rhizoma Chuanxiong-Fructus Lycii-Semen Vaccariae-Radix Polygalae. According to the frequency of use，the four qi of medicines was in the order of warm，neutral，cold，cool and hot，and was mainly warm；the five flavors of medicines was in the order of sweet，bitter，acrid，sour，salty and astringent，with sweet flavor as the main flavor；the top five meridian entry of medicines were liver meridian， spleen meridian， kidney meridian， lung meridian and heart meridian. Conclusion：Based on data mining，it is found that Professor LI Qixin treated erectile dysfunction by fortifying the spleen and tonifying the kidney， as well as soothing the liver and activating blood； the main flavors of commonly used medicines are warm，neutral and sweet，and the treatment was modified according to the symptoms.