Abstract： Objective： To observe the clinical effect of the therapy of self- made Wenshen Jianpi tang combined with mesalazine on ulcerative colitis(UC) and its effect on the score of mirror image of intestinal mucosal， recurrence rate and inflammatory factors. Methods：A total of 86 patients with UC were selected and divided into the treatment group and the control group according to the random number table method， with 43 cases in each group. The control group was treated with mesalazine，and the treatment group was additionally treated with Wenshen Jianpi tang based on the treatment of the control group. Before and after treatment， the changes of scores of Chinese medicine syndrome and mirror image of intestinal mucosa and levels of inflammatory factors，including tumor necrosis factor-α(TNF-α)，interleukin-17(IL-17) and interleukin-23(IL-23)，were compared between the two groups，and the clinical effects，incidence of adverse reactions and recurrence rates were counted. Results： The total effective rate was 95.35% in the treatment group， higher than that of 79.07% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference in the comparison of scores of Chinese medicine syndrome and mirror image of intestinal mucosa between the two groups(P＞ 0.05)；after treatment，the scores of Chinese medicine syndrome and mirror image of intestinal mucosa in the two groups were decreased when compared with those before treatment(P＜0.05)， and the two scores in the treatment group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference in the comparison of levels of serum TNF- α，IL-17 and IL-23 between the two groups(P＞0.05)；after treatment，the above levels in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of inflammatory indexes in the treatment group were lower than those in the control group(P＜0.05). The recurrence rate was 2.44% in the treatment group and 23.53% in the control group after 6 months follow- up， the difference being statistically significant(P＜0.05). After treatment， the incidence of adverse reactions was 4.65% in the treatment group and 23.26% in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Wenshen Jianpi tang combined with mesalazine has a significant clinical effect on UC，which can effectively improve the scores of Chinese medicine syndrome and mirror image of intestinal mucosal，alleviate the inflammatory responses of the body，and reduce the recurrence rate and the incidence of adverse reactions.