Abstract： Objective： To observe the clinical effect of Qingfei Huatan prescription combined with azithromycin for mycoplasma pneumonia in children. Methods：A total of 105 cases of children with mycoplasma pneumonia were divided into the treatment group and the control group according to the random number table method，with 65 and 40 cases in each group respectively. After admission， both groups were given routine symptomatic treatment； the control group was additionally treated with azithromycin，and the treatment group was additionally treated with Qingfei Huatan prescription based on the treatment of the control group. After three weeks of treatment，clinical effects，Chinese medicine syndrome scores，lung function indexes including forced vital capacity(FVC)，forced expiratory volume in one second(FEV1) and FEV1/FVC，as well as the levels of serum inflammatory factors including interleukin-6(IL-6)，interleukin-8(IL-8))，tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) in the two groups were evaluated. Results：The total curative effective rate was 93.85% in the treatment group and 80.00% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P＞0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the score in the treatment group was lower than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the levels of FVC， FEV1 and FEV1/FVC between the two groups(P＞0.05). After treatment，the above indexes of lung function in the two groups were significantly increased when compared with those before treatment(P＜0.05)，and the above indexes in the treatment group were higher than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of IL- 6，IL- 8，TNF- α and CRP between the two groups(P＞0.05)；after treatment，the levels of the above inflammatory factors in the two groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above indexes in the treatment group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Qingfei Huatan prescription combined with azithromycin for mycoplasma pneumonia in children has a definite curative effect， and can significantly relieve their clinical symptoms， improve lung function and inflammatory responses. It has a better curative effect than simple azithromycin.