Abstract：Objective：To observe the clinical effect of Kaihoujian sprays combined with cefatriaxone sodiu for injection for acute suppurative tonsillitis in children. Methods：A total of 98 cases of children with acute suppurative tonsillitis were divided into the control group and the observation group according to the random number table method，with 49 cases in each group. The control group was treated with intravenous drip of ceftriaxone sodium for injection， and the observation group was additionally treated with Kaihoujian sprays based on the treatment of the control group. Both groups were treated for seven days. After treatment，clinical effects，incidence of adverse reactions，as well as the time of temperature recovered，tonsil congestion subsided，purulent secretion disappeared and throat pain disappeared were compared between the two groups. The scores of primary and secondary symptoms， neutrophils， C- reactive protein and leukocyte count in the two groups before and after treatment were compared. Results： The total effective rate was 95.92% in the observation group and 77.55% in the control group，the difference being significant(P＜0.05). The time of temperature recovered，tonsil congestion subsided，purulent secretion disappeared and throat pain disappeared in the observation group was shorter than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of scores of primary and secondary symptoms between the two groups(P＞0.05). After treatment， scores of primary and secondary symptoms in the two groups were decreased when compared with those before treatment， and the two scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of leukocyte counts，neutrophils，and C-reactive protein levels between the two groups(P＞ 0.05). After treatment， leukocyte counts， neutrophils， and C- reactive protein levels in the two groups were decreased when compared with those before treatment，and the above indexes in the observation group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 8.16% in the observation group and 6.12% in the control group， there being no significance in the difference(P＞0.05). Conclusion： Kaihoujian sprays combined with cefatriaxone sodiu for injection has a defined curative effect and relatively high safety in the treatment of children with acute suppurative tonsillitis.