Abstract：Objective：To observe the clinical effect of the therapy of compound Muniziqi granules combined with intense pulsed light on chloasma and its effect on the levels of sex hormones in patients. Methods：A total of 88 cases of patients with chloasma were selected and divided into the control group and the study group according to random number table method，with 44 cases in each group. The study group was given the therapy of compound Muniziqi granules combined with intense pulsed light， and the control group was treated with vitamin E and vitamin C. Both groups were treated for three months. The clinical effect， scores of skin lesion color and skin lesion area as well as the estrogen levels before and after treatment were compared. Results： The healing rate was 90.91% in the study group， higher than that of 65.91% in the control group(P＜0.05). After treatment，the scores of skin lesion color and skin lesion area in both groups were decreased when compared with those before treatment(P＜0.05)，and the above two scores in the study group were lower than those in the control group(P＜0.05). After treatment， the levels of follicle stimulating hormone(FSH)， luteinizing hormone(LH) and estradiol(E2) in both groups were decreased when compared with those before treatment(P＜0.05)， and the above three levels in the study group were lower than those in the control group(P＜0.05). Conclusion：The therapy of compound Muniziqi granules combined with intense pulsed light has a definite clinical effect on the treatment of chloasma，which can effectively improve the skin lesions and reduce the levels of sex hormones.