Abstract：Objective：To observe the clinical effect of Baihe Gujin tang combined with docetaxe and platinum drugs for advanced non- small cell lung cancer. Methods：A total of 180 cases of patients with advanced non- small cell lung cancer were divided into the control group and the study group according to the random number table method，with 90 cases in each group. The control group was treated with routine docetaxel+carboplatin chemotherapy，and the study group was additionally treated with Baihe Gujin tang based on the treatment of the control group. Both groups were treated for six weeks. The clinical effects in the two groups were compared. Before and after treatment，the levels of cytokeratin 19 fragment(CYFRA21- 1)， carcinoembryonic antigen(CEA)，carbohydrate antigen 125(CA125)，neuron-specific enolase(NSE)，immunoglobulin G(IgG)， immunoglobulin A(IgA)，and immunoglobulin M(IgM) and the scores of Quality of Life Questionnaire-Lung Cancer 13(QLQLC13) in the two groups were compared. Results： The disease control rate(DCR) and objective response rate(ORR) were 93.3% and 74.4% in the study group and 87.8% and 56.7% in the control group，differences being significant(P＜0.05). After treatment，the levels of CYFRA21-1，CEA，CA125 and NSE in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the indexes in the study group were lower than those in the control group(P＜ 0.05). There was no significant difference being found in the comparison of IgG level in the study group before and after treatment(P＞0.05)， and the IgG level in the control group was decreased when compared with that before treatment(P＜ 0.05)，and the IgG level in the study group was higher than that in the control group(P＜0.05)；the levels of IgA and IgM in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of IgA and IgM in the study group were higher than those in the control group(P＜0.05). After treatment， the scores of general symptoms， function and lung cancer symptom in QLQ- LC13 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the total scores of health status were increased(P＜0.05). The scores of general symptoms and lung cancer symptom in the study group were lower than those in the control group(P＜0.05)； and there was no significant difference in the comparison of function and total score of health status between the study group and the control group(P＞ 0.05). Conclusion： Docetaxel + carboplatin combined with Baihe Gujin tang for advanced non- small cell lung cancer can improve clinical effects，quality of life and immune function，and reduce levels of tumor markers.