Abstract：Objective：To observe the clinical effect of the therapy of auricular point pressing with beans combined with escitalopram oxalate tablets on depression and its effect on neurotransmitter in patients. Methods：A total of 80 patients with depression were divided into the control group and the observation group according to the random number table method， with 40 cases in each group. The control group was treated with escitalopram oxalate tablets，and the observation group was additionally treated with auricular point pressing with beans based on the treatment of the control group. Both groups were treated for one month. The clinical effects in the two groups were compared. Before and after treatment， the scores of Hamilton Rating Scale for Depression(HAMD)， syndrome scores and levels of neurotransmitter expression were compared between the two groups. Results：The total effective rate was 90.00% in the observation group，higher than that of 72.50% in the control group(P＜0.05). After treatment，the scores of HAMD in the two groups were decreased when compared with those before treatment(P＜0.05)，and the score of HAMD in the observation group was lower than that in the control group (P＜0.05). After treatment， the scores of depression， sleep disorder and retardation of thinking in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05). After treatment， the levels of norepinephrine(NE)， 5- hydroxytryptamine(5- HT)， dopamine(DA)，glutamate(Glu) and γ-aminobutyric acid(GABA) in the two groups were increased when compared with those before treatment(P＜0.05)， and the above levels in the observation group were higher than those in the control group(P＜ 0.05). Conclusion： The therapy of auricular point pressing with beans combined with escitalopram oxalate tablets for depression can effectively alleviate the clinical symptoms of patients and regulate the expression level of neurotransmitters， with great antidepressant effect.