Abstract：This paper introduces the clinical experience of Professor CAI Shenchu treating insomnia. The common type of insomnia is heart-kidney non-interaction type，and the main treatment is to warm the kidney water and drain the heart fire. Professor CAI holds that the middle should be treated when there is non-interaction between the heart and the kidney. There are three pathogenesis of the disease，namely phlegm- damp obstruction and the disorder of upward and downward，qiblood deficiency and lack of nourishing in the heart and the kidney，and cold，heat，deficiency and excess in complexity and derangement of qi movement. There are three treatment principles and methods； the treatment should pay attention to resolving phlegm and regulating qi movement，and the modified combination of Banxia Houpu tang，Zhishu pills and Banxia Shumi tang should be applied； the patients should supplement qi and nourish blood， focus on the consolidation of the middle，and be treated with modified Huangqi Jianzhong tang and Guizhi Gancao Longgu Muli tang；cold and heat as well as deficiency and excess should be regulated，and the main prescription is Banxia Xiexin tang and Suanzaoren tang. Therefore， the treatment should not be limited to the heart and the kidney，but to grasp the whole with syndrome differentiation and treatment of the middle energizer，the spleen，and stomach，and modified use of classical prescriptions.