Abstract：Objective：To observe the curative effect of Bushen Huayu prescription combined with western medicine for infertility with polycystic ovary syndrome(PCOS). Methods：A total of 78 cases of PCOS patients were selected and divided into the treatment group and the control group according to the random number table method，with 40 and 38 cases in each group respectively. The control group was treated with western medicine，and the treatment group was additionally treated with Bushen Huayu prescription based on the treatment of the control group. The clinical effects in the two groups were compared；Chinese medicine syndrome scores and the changes in the levels of sex hormones including luteinizing hormone (LH)， testosterone(T) and estradiol(E2) before and after treatment in the two groups were compared； ovulation rates and pregnancy rates after three months in the two groups were followed up and observed. Results：After treatment，the total effective rate of clinical effect was 90.00% in the treatment group and 68.42% in the control group， the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment， and the score in the treatment group was lower than that in the control group， differences being significant(P＜0.05). After treatment， the levels of T and LH in serum in the two groups were decreased when compared with those before treatment， and serum E2 levels were increased， differences being significant(P＜0.05). After treatment，the levels of T and LH in serum in the treatment group were lower than those in the control group，and serum E2 level was higher，differences being significant(P＜0.05). After treatment and during three-month follow-up and observation， the ovulation rate and pregnancy rate in the treatment group were higher than those in the control group，differences being significant(P＜0.05). Conclusion： The therapy of Bushen Huayu prescription combined with western medicine for infertility with PCOS can regulate the levels of serum sex hormones， alleviate the clinical symptoms of patients and improve the curative effect，ovulation rate and pregnancy rate.