Abstract：Objective：To analyze the administration rule and compatibility law of Prof. ZOU Yihuai in treating insomnia by using data mining technology， and to explore his academic thoughts and characteristics in the treatment of insomnia. Methods： The prescriptions of Prof. ZOU Yihuai， who works in Dongzhimen Hospital of Beijing University of Chinese Medicine， from January 2019 to June 2021 were collected， and the selected prescriptions were analyzed by frequency analysis， association rules， complex entropy clustering analysis and other data mining methods via Chinese Medicine Inheritance Assistant System V2.5. Results：A total of 131 prescriptions were collected，involving 90 kinds of Chinese herbs. Among them， cold and warm herbs accounted for the majority in terms of natures， and acrid， sweet and bitter herbs accounted for a large proportion in terms of flavors；the herbs mainly entered into the heart and liver channels. The top five herbs in use frequency were Poria， Semen Platycladi， FlosChrysanthemi， PericarpiumCitriReticulatae and FructusCitriSarcodactylis. The most frequently used herbal combinations were Semen Platycladi- Poria，FlosChrysanthemi- Poria ， Semen Platycladi-FlosChrysanthemi ， PericarpiumCitriReticulatae-Poria and PericarpiumCitriReticulatae-Semen Platycladi. A total of 14 core herbal combinations were excavated， and seven new prescriptions were developed and obtained. Conclusion：Based on the theory of “the mind governs the sleep” and by taking the core treatment method of “harmonizing the mind and calming the sleep”，Prof. ZOU Yihuai uses the methods of regulating qi and elevating the mind， clearing heat and calming the mind，nourishing the blood and tranquilizing the mind，and tranquilizing the heart and calming the mind to treat the four states of "restless mind"-stagnated mind，agitated mind，negative mind and dissipated mind. He administers the medicine with precision，balances yin and yang，and restores circadian rhythm.