Abstract： Objective： To discuss the clinical effect of Danggui Sini tang combined with amoxicillin and clavulanate potassium tablets for chronic pelvic inflammatory disease and its effects on inflammatory factors in serum and immune function. Methods： A total of 60 cases of patients with chronic pelvic inflammatory disease were selected and randomly divided into the treatment group and the control group， with 30 cases in each group. The control group was treated with amoxicillin and clavulanate potassium tablets，and the treatment group was additionally treated with Danggui Sini tang based on the treatment of the control group. Before and after treatment，serum inflammatory factors [tumor necrosis factor-α(TNF-α)， interleukin-21(IL-21)，interleukin-6(IL-6)] and immune function indexes[immunoglobulin-G(IgG)，immunoglobulin-A(IGA)， immunoglobulin-m(IgM)] were detected in the two groups. Curative effect and incidence of adverse reactions were observed. Results：The total effective rate was 96.67% in the treatment group，and 76.67% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of TNF-α， IL- 21 and IL- 6 between the two groups(P＞0.05). After treatment， levels of TNF- α and IL- 21 in the two groups were decreased when compared with those before treatment(P＜0.05)，and IL-6 levels were increased(P＜0.05)；levels of TNF-α and IL-21 in the treatment group were lower than those in the control group(P＜0.05)，and IL-6 level was higher(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of IgA，IgG，and IgM in serum between the two groups(P＞0.05). After treatment，levels of IgA，IgG，and IgM in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in the treatment group were lower than those in the control group(P＜0.05). The incidence of adverse reactions was 3.33% in the treatment group，and 26.67% in the control group， the difference being significant(P＜0.05). Conclusion： Danggui Sini tang combined with amoxicillin and clavulanate potassium tablets has a significant curative effect in the treatment of chronic pelvic inflammatory disease， which can effectively reduce inflammatory responses，and enhance body immune function with fewer adverse reactions.