Abstract：Objective：To observe the clinical effect of modified Jieyu tang combined with aripiprazole for schizophrenia and its effect on serum inflammatory factors. Methods：A total of 124 cases of patients with schizophrenia were selected and divided into the control group and the treatment group according to the random number table method，with 62 cases in each group. The control group was treated with aripiprazole，and the treatment group was additionally treated with modified Jieyu tang based on the treatment of the control group. After four-week treatment， clinical effects were evaluated， and a sixmonth follow-up was carried out. The total effective rates，syndrome scores，levels of inflammatory factors[interleukin-1β (IL-1β)，interleukin-6(IL-6)，interleukin-12(IL-12)，and tumor necrosis factor-α(TNF-α)]，adverse reactions and recurrence rates were compared between the two groups. Results： The total effective rate was 96.77% in the treatment group and 74.19% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of syndrome scores between the two groups(P＞0.05). After treatment， scores of mental depression，apathy，incoherent speech，chest oppression and sighing，red tongue without tongue fur in the two groups were lower than those before treatment(P＜0.05)，and the above syndrome scores in the treatment group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of IL-1β，IL-6，IL-12 and TNF-α between the two groups(P＞0.05)；after treatment，levels of above inflammatory factors in the two groups were lower than those before treatment(P＜0.05)，and the above indexes in the treatment group were lower than those in the control group(P＜0.05). During treatment，the incidence of adverse reactions was 3.23% in the treatment group and 6.45% in the control group，there was no significant difference being found in the comparison(P＞0.05). During six-month follow-up，the recurrence rate was 1.61% in the treatment group and 11.29% in the control group，the difference being significant(P＜0.05). Conclusion： Modified Jieyu tang combined with aripiprazole can enhance the shortterm curative effect of patients with schizophrenia，reduce syndrome scores and inflammatory factors levels，and achieve a good long-term curative effect，without the increase of incidence of adverse reactions