Abstract： Objective： To observe the clinical effect of modified Danggui Yinzi combined with loratadine for atopic dermatitis of blood deficiency and wind- dryness type. Methods： A total of 102 cases of patients with atopic dermatitis of blood deficiency and wind-dryness type were selected and divided into the control group and the observation group according to the random number table method，with 51 cases in each group. The control group was treated with loratadine tablets，and the observation group was additionally given modified Danggui Yinzi based on the treatment of the control group. Both groups were treated for four weeks. The Scoring Atopic Dermatitis(SCORAD)， pruritus degree， skin barrier function and clinical effects in the two groups were compared. The pruritus degree was evaluated by Visual Analogue Scale(VAS). Results：After treatment，the scores of SCORAD and VAS in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the observation group were lower than those in the control group(P＜0.05). After treatment， sebum content and stratum corneum hydration in the two groups were increased when compared with those before treatment(P＜0.05)， and TEWL were decreased(P＜0.05)； sebum content and stratum corneum hydration in the observation group were higher than those in the control group(P＜0.05)，and TEWL was lower(P＜0.05). The total effective rate was 96.08% in the observation group， higher than that of 80.39% in the control group(P＜0.05). Conclusion： The therapy of modified Danggui Yinzi combined with loratadine for atopic dermatitis of blood deficiency and wind- dryness type has a good curative effect，which can relieve pruritus and improve skin barrier function.