Abstract:Objective:To observe the clinical effect of modified Shenghui tang combined with Donepezil on senile mild cognitive impairment with kidney essence depletion syndrome. Methods: A total of 82 elderly patients with mild cognitive impairment with kidney essence depletion syndrome were selected and divided into the control group and the observation group by random number table method, with 41 cases in each group. The control group was treated with Donepezil hydrochloride capsules, and the observation group was additionally treated with modified Shenghui tang based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effect as well as scores of Montreal Cognitive Assessment(MoCA), Barthel Index and Delayed Verbal Recall(DVR) before and after treatment were compared between the two groups. Results:The effective rate was 87.80% in the observation group,higher than that of 68.29% in the control group(P<0.05). After treatment,the scores of MoCA,Barthel Index and DVR in both groups were increased when compared with those before treatment(P<0.05),and the above three scores in the observation group were higher than those in the control group(P<0.05). Conclusion:The therapy of modified Shenghui tang combined with Donepezil for senile mild cognitive impairment with kidney essence depletion syndrome can effectively improve the cognitive function and quality of life of patients.