Abstract:Objective:To observe the clinical effect of Shexiang Baoxin pills combined with western medicine for coronary heart disease. Methods: A total of 176 cases of patients with coronary heart disease were selected and divided into the observation group and the control group randomly,with 88 cases in each group. The control group was treated with aspirin enteric- coated tablets and clopidogrel bisulfate tablets , and the observation group was additionally treated with Shexiang Baoxin pills based on the treatment of the control group. Both groups were treated for three months. The clinical effects and the incidences of myocardial infarction in the two groups were compared;the indexes of oxidative stress,liver function and kidney function before and after treatment in the two groups were compared. Results:The total effective rate was 97.7% in the observation group,higher than that of 87.5% in the control group(P<0.05). The incidence of myocardial infarction was 4.5% in the observation group,lower than that of 14.8% in the control group(P<0.05). After treatment,the levels of superoxide dismutase(SOD) were increased when compared with those before treatment, and the levels of malondialdehyde(MDA) were decreased(P<0.05);the SOD level in the observation group was higher than that in the control group(P<0.05), and the MDA level was lower(P<0.05). In the comparison of the levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST),blood urea nitrogen(BUN) and creatinine(Cr) in the two groups before and after treatment as well as the comparison of the above indexes between the two groups,there was no significance in the difference(P>0.05). Conclusion:The therapy of Shexiang Baoxin pills combined with western medicine for coronary heart disease has a definite curative effect,which can effectively improve the oxidative stress indexes of patients and reduce the incidence of myocardial infarction with high safety.