Abstract： Objective： To observe the clinical effect of Guanxinning tablets for pulmonary heart disease in acute exacerbation with qi stagnation and blood stasis syndrome. Methods：A total of 110 cases of patients with pulmonary heart disease in acute exacerbation with qi stagnation and blood stasis syndrome were selected and divided into the control group and the observation group according to the random number table method，with 55 cases in each group. The control group was given routine symptomatic treatment，and the observation group was additionally given Guanxinning tablets based on the treatment of the control group. Both groups were continuously treated for four weeks. The heart function and lung function before and after treatment as well as the clinical effects were compared between the two groups. Results： The total effective rate was 94.55% in the observation group， higher than that of 80.00% in the control group(P＜0.05). After treatment， left ventricular ejection fraction(LVEF)， stroke output(SV)， cardiac output(CO)， prcentage of forced expiratory volume in the first second to the expected value(FEV1%pred) and forced expiratory volume in the first second(FEV1) forced vital capacity(FVC) in the two groups were increased when compared with those before treatment(P＜0.05)， and the above indexes in the observation group were higher than those in the control group(P＜0.05). Conclusion：Guanxinning tablets has a relatively good curative effect on pulmonary heart disease in acute exacerbation with qi stagnation and blood stasis syndrome and can effectively improve the heart function and lung function.