Abstract： Objective： To observe the clinical effect of Shugan Jieyu capsules combined with ziprasidone for schizophrenia， and its effect on cognitive function and levels of vascular endothelial growth factor(VEGF)， glial- cell line derived neurotrophic factor(GDNF) and epidermal growth factor(EGF). Methods： A total of 80 cases of patients with schizophrenia were selected and divided into the control group and the observation group according to the random number table method，with 40 cases in each group. The control group was treated with ziprasidone，and the observation group was additionally treated with Shugan Jieyu capsules based on the treatment of the control group. Both groups were treated for eight weeks. The clinical effects and incidence of adverse reactions in the two groups were compared. Before and after treatment，the cognitive function and levels of VEGF，GDNF and EGF in the two groups were compared. Results：The total effective rate was 95.00% in the observation group， higher than that of 77.50% in the control group(P＜0.05). After treatment，the scores of negative symptoms，positive symptoms and general psychopathological symptoms as well as the total scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores of negative symptoms， positive symptoms and general psychopathological symptoms as well as the total score in the observation group were lower than those in the control group(P＜0.05). After treatment， the scores of each dimension of MATRICS Consensus Cognitive Battery(MCCB) in the two groups were increased when compared with those before treatment(P＜0.05)， and the scores of each dimension of MCCB in the observation group were higher than those in the control group(P＜0.05). After treatment， the levels of VEGF and GDNF in the two groups were increased when compared with those before treatment(P＜0.05)， and the EGF levels were decreased(P＜0.05)； the levels of VEGF and GDNF in the observation group were higher than those in the control group(P＜0.05)，and the EGF level was lower(P＜0.05). The incidence of adverse reactions was 15.00% in the observation group，compared with that of 12.50% in the control group，there was no significant difference(P＞0.05). Conclusion：Shugan Jieyu capsules combined with ziprasidone for schizophrenia can improve clinical effects and cognitive function of patients，and regulate the levels of VEGF，GDNF and EGF with good safety.