Abstract： Objective： To observe the clinical effect of Shumian capsules combined with venlafaxine for depression complicated with insomnia. Methods：A total of 76 depression patients complicated with insomnia were selected and divided into the control group and the observation group according to the random number table method，with 38 cases in each group. The control group was treated with venlafaxine， and the observation group was treated with Shumian capsules combined with venlafaxine. Both groups were treated for six weeks. Before and after treatment，the scores of Hamilton Rating Scale for Depression- 17(HAMD- 17)， Self- Rating Depression Scale(SDS)， Pittsburgh Sleep Quality Index(PSQI) and Barthel Index were compared between the two groups， and the clinical effects in the two groups were compared. Results： After treatment，the scores of HAMD-17，SDS and PSQI in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three scores in the observation group were lower than those in the control group(P＜0.05). After treatment，the scores of Barthel Index in both groups were increased(P＜0.05)，and the score of Barthel Index in the observation group was higher(P＜0.05). The total effective rate was 94.74% in the observation group， higher than that of 73.68% in the control group(P＜0.05). Conclusion： The therapy of Shumian capsules combined with venlafaxine has a significant curative effect on depression complicated with insomnia，which can reduce the degree of depression in patients and improve their sleep quality and ability of daily living.