Abstract：Objective：To observe the clinical effect of the therapy of Suting Maxing Shigan tang combined with routine western medicine on acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with phlegm- heat constraining the lung syndrome. Methods：A total of 80 AECOPD patients with phlegm-heat constraining the lung syndrome were divided into the experiment group and the control group according to the random number table method，with 40 cases in each group. One case in the experiment group failed to adhere to medication and dropout；one case in the control group was excluded because of the refusal to review the indexes of the curative effect， and a total of 78 patients completed the clinical observation. Both groups were treated with routine western medicine， and the experiment group was additionally treated with Suting Maxing Shigan tang. Fourteen days after treatment，the clinical effects，Chinese medicine syndrome scores and levels of inflammatory indexes[neutrophil- to- lymphocyte ratio(NLR)， high- sensitivity C- reactive protein(hs- CRP) and procalcitonin(PCT)]，coagulation indexes[fibrinogen(Fib) and D- dimer(D- D)]，the lung function [forced expiratory volume in one second(FEV1)，FEV1/FVC and FEV1 percentage in the predicted value(FEV1%)] and indexes of blood gas analysis [partial pressure of oxygen(PaO2)，partial pressure of carbon dioxide(PaCO2) and oxygen saturation(SaO2)] were compared between the two groups. Results：The remarkably effective rate was 69.23% in the experiment group，and was 28.21% in the control group， the difference being significant(P＜0.05). Before treatment， there was no significant difference being found in the comparison of Chinese medicine syndrome scores and total scores of cough， expectoration， shortness of breath， wheezing，cyanosis and rales between the two groups(P＞0.05)；after treatment，the scores and total scores of the above syndromes in the two groups were decreased when compared with those before treatment(P＜0.05)，and the scores in the experiment group were lower than those in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of NLR，hs-CRP and PCT between the two groups(P＞0.05)；after treatment，the above levels in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above levels in the experiment group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of Fib and D-D between the two groups(P＞0.05)；after treatment，the above indexes in two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the experiment group were lower than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of FEV1，FEV1/FVC and FEV1% between the two groups(P＞0.05)；after treatment， the above indexes in the two groups were increased when compared with those before treatment(P＜0.05)，and the above indexes in the experiment group were higher than those in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of PaO2，PaCO2 and SaO2 between the two groups(P＞0.05). After treatment，the levels of PaO2 and SaO2 in the two groups were increased when compared with those before treatment (P＜0.05)，and levels of PaCO2 were decreased(P＜0.05)；the levels of PaO2 and SaO2 in the experiment group were higher than those in the control group(P＜0.05)，and the level of PaCO2 was lower(P＜0.05). During treatment，no obvious adverse reactions occurred in both groups. Conclusion： The therapy of Suting Maxing Shigan tang combined with routine western medicine for AECOPD with phlegm-heat constraining the lung syndrome can improve the clinical effect，effectively control the inflammatory responses，enhance the lung function，and reduce coagulation function with high safety.