Abstract：Objective：To observe the clinical effect of warm-needling moxibustion combined with clomiphene citrate for infertility with polycystic ovary syndrome(PCOS) and its effect on sex hormones and ovulation. Methods：A total of 80 cases of PCOS patients with infertility were divided into the control group and the treatment group according to odd-even number method，with 40 cases in each group. The control group was treated with clomiphene citrate，and the treatment group was given warm- needling moxibustion combined with clomiphene citrate. After treatment for three menstrual cycles， clinical effects，Chinese medicine syndrome scores，serum sex hormones levels，ovulation and pregnancy state were evaluated in the two groups. Results：After treatment，the total effective rate was 87.50% in the treatment group，and 67.50% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of Chinese medicine symptom scores between the two groups(P＞0.05). After treatment，Chinese medicine symptom scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the decrease of scores in the treatment group was more significant than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of follicle-stimulating hormones(FSH)，luteinizing hormone(LH)，and testosterone(T) in serum between the two groups(P＞0.05). After treatment，levels of LH and T in serum in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the two levels in the treatment group were lower than those in the control group(P＜0.05)； levels of serum FSH in the two groups were increased when compared with those before treatment(P＜0.05)，and the FSH level in the treatment group was higher than that in the control group(P＜0.05). After treatment，the ovulation rate and pregnancy rate in the treatment group were 82.50% and 42.50% respectively，and those in the control group were 60.00% and 20.00% respectively，differences being significant (P＜0.05). Conclusion： Warm- needling moxibustion combined with clomiphene citrate has a defined curative effect in the treatment of infertility with PCOS， which can improve clinical symptoms， regulate sex hormone levels， and improve ovulation rate and pregnancy rate.