Abstract： Objective： To observe the effect of Shexiang Baoxin pills combined with isosorbide mononitrate tablets on vascular endothelial function and myocardial injury markers in patients with unstable angina pectoris(UAP). Methods：A total of 64 cases of patients with UAP of qi stagnation and blood stasis type were selected and divided into the treatment group and the control group according to the random number table method， with 32 cases in each group. Both groups were given routine therapy of modern medicine，the control group was treated with isosorbide mononitrate tablets，and the treatment group was treated with Shexiang Baoxin pills based on the treatment of the control group. Both groups were treated for four weeks. The clinical effects in the two groups were observed. Before and after treatment， the changes in the condition of angina attacks，including frequency，duration and scores of degree，the four levels of blood lipid including total cholesterol (TC)， triglyceride(TG)， low density lipoprotein cholesterol(LDL- C) and high- density lipoprotein- cholesterol(HDL- C)， the vascular endothelial function including nitric oxide(NO) and endothelin(ET)， and myocardial injury markers including creatine kinase muscle-brain(CK-MB) and N-terminal pro-B-type natriuretic peptide(NT-proBNP) before and after treatment in the two groups were compared. Results： The total effective rate of clinical effects was 90.63% in the treatment group and 68.75% in the control group，the difference being significant(P＜0.05). After treatment，the frequency and duration of angina attacks and the scores of degree in the two groups were decreased when compared with those before treatment，and the above three values in the treatment group were lower than those in the control group，differences being significant(P＜0.05). After treatment， the levels of TC， TG and LDL- C in the two groups were decreased when compared with those before treatment，and the HDL-C levels were increased，differences being significant(P＜0.05). After treatment，the levels of TC， TG and LDL-C in the treatment group were lower than those in the control group，and HDL-C level was higher，differences being significant(P＜0.05). After treatment，the NO levels in serum in the two groups were increased when compared with those before treatment， and ET levels were decreased， differences being significant(P＜0.05). After treatment， the NO level in serum in the treatment group was higher than that in the control group，and ET level was lower，differences being significant(P＜0.05). After treatment， the values of CK- MB and NT- proBNP in the two groups were decreased when compared with those before treatment，and the above two values in the treatment group were lower than those in the control group， differences being significant(P＜0.05). Conclusion： Shexiang Baoxin pills combined with isosorbide mononitrate tablets can improve the clinical symptoms，myocardial injury and clinical effects in UAP patients，reduce the levels of blood lipid，and protect the vascular endothelial cells.