补肺益肾平喘汤联合沙美特罗替卡松治疗慢性阻塞性肺疾病稳定期临床研究
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Clinical Study on Bufei Yishen Pingchuan Tang Combined with Salmeterol Rottica⁃ sone for Chronic Obstructive Pulmonary Disease at Stable Stage
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    摘要:

    目的:观察补肺益肾平喘汤联合沙美特罗替卡松治疗慢性阻塞性肺疾病(COPD) 稳定期的临床疗效。方法:选取COPD 稳定期患者78 例,按随机数字表法分为对照组和观察组各39 例。对照组予沙美特罗替卡松吸入治疗,观察组在对照组基础上加补肺益肾平喘汤治疗,2 组均连用12 周。比较2 组临床疗效,检测治疗前后肺功能指标第1 秒用力呼气容积(FEV1)、用力肺活量(FVC) 及FEV1/FVC 比值,比较2 组呼吸困难量表(mMRC) 评分和慢性阻塞性肺病评估量表(CAT) 评分变化。结果:观察组总有效率为94.87%,高于对照组79.49%,差异有统计学意义(P<0.05)。治疗前,2 组FEV1、FVC 及FEV1/FVC 比较,差异无统计学意义(P>0.05)。治疗后,2 组FEV1、FVC 及FEV1/FVC 较治疗前升高,且观察组FEV1、FVC 及FEV1/FVC 高于对照组,差异有统计学意义(P<0.05)。治疗前,2 组mMRC 评分、CAT 评分比较,差异无统计学意义(P>0.05)。治疗后,2 组mMRC 评分、CAT 评分较治疗前下降(P<0.05),且观察组mMRC 评分、CAT 评分低于对照组(P<0.05)。结论:补肺益肾平喘汤联合沙美特罗替卡松治疗COPD 稳定期患者的疗效确切,能明显改善临床症状及肺功能。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Bufei Yishen Pingchuan tang combined with salmeterol rotticasone for chronic obstructive pulmonary disease(COPD) at stable stage. Methods:A total of 78 cases of COPD patients at stable stage were selected and divided into the control group and the observation group,with 39 cases in each group. The control group was given salmeterol rotticasone inhalation, and the observation group was additionally treated with Bufei Yishen Pingchuan tang based on the treatment of the control group. Both groups were treated for 12 weeks. Clinical effects were compared between the two groups. The lung function indexes including forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and the ratio of FEV1 to FVC before and after treatment were detected. Changes in scores of Modified Medical Research Council(mMRC) and COPD Assessment Test(CAT) were compared between the two groups. Results:The total effective rate was 94.87% in the observation group, higher than that of 79.49% in the control group, the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of FEV1,FVC and FEV1/FVC between the two groups(P>0.05). After treatment, FEV1, FVC and FEV1/FVC in the two groups were increased when compared with those before treatment, and the three indexes in the observation group were higher than those in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of scores of mMRC and CAT between the two groups(P>0.05). After treatment,scores of mMRC and CAT in the two groups were decreased when compared with those before treatment,and the scores of mMRC and CAT in the observation group were lower than those in the control group(P<0.05). Conclusion:Bufei Yishen Pingchuan tang combined with salmeterol rotticasone has a defined curative effect in the treatment of COPD patients at stable stage, and it can more effectively improve clinical symptoms and the lung function.

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苏杭,王俊升,郑敏超.补肺益肾平喘汤联合沙美特罗替卡松治疗慢性阻塞性肺疾病稳定期临床研究[J].新中医,2022,54(11):92-95

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  • 在线发布日期: 2022-06-10
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