Abstract： Objective： To observe the clinical effect of Zhuyu Dingchuan tang combined with acupuncture and moxibustion for acute exacerbation of chronic obstructive pulmonary disease(AECOPD) with phlegm- stasis obstructing the lung syndrome. Methods：A total of 80 cases of AECOPD patients were selected and divided into the control group and the observation group according to different treatment methods， with 40 cases in each group. The control group was given routine modern medicine treatment， and the observation group was additionally treated with Zhuyu Dingchuan tang combined with acupuncture and moxibustion based on the treatment of the control group. Both groups were continuously treated for 14 days. Clinical effects were compared between the two groups. The changes in Chinese medicine syndrome scores， serum inflammatory factors [interleukin- 6(IL- 6)， C- reactive protein(CRP)]， indexes of lung function [forced vital capacity(FVC)， forced expiratory volume in the first second(FEV1)， FEV1/FVC]， and indexes of hemorheology[erythrocyte sedimentation rate(ESR)，red cell aggregation index(RAI)，hematocrit(HCT)，plasma viscosity(PV)，high shear and low shear] were compared between the two groups before and after treatment. The incidence of adverse reactions in the two groups was observed. Results：After treatment，the total effective rate of clinical effect was 92.50% in the observation group and 75.00% in the control group，the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the score in the observation group was lower than that in the control group，differences being significant(P＜0.05). After treatment，levels of IL-6 and CRP in serum in the two groups were decreased when compared with those before treatment，and the two levels in the observation group were lower than those in the control group，differences being significant(P＜0.05). After treatment，values of FVC and FEV1/ FVC in the two groups were increased when compared with those before treatment，and the two values in the observation group were higher than those in the control group， differences being significant(P＜0.05). After treatment， the indexes of ESR， RAI， HCT， PV， high shear and low shear in the two groups were decreased when compared with those before treatment，and the above six indexes in the observation group were lower than those in the control group，differences being significant(P＜0.05). There was no significant adverse reaction during treatment in the two groups. Conclusion： Zhuyu Dingchuan tang combined with acupuncture and moxibustion has a defined curative effect in the treatment of AECOPD. It can effectively improve lung function and inflammatory symptoms with high safety.