Abstract： Objective： To observe the clinical effect of Shenshuaining tablets combined with compound α- ketoacid tablets for chronic renal failure(CRF). Methods：A total of 90 cases of CRF patients were given a retrospective analysis of their clinical data，and divided into the control group and the observation group according to the treatment methods in the data， with 45 cases in each group. The control group was given oral administration of compound α- ketoacid tablets， and the observation group was additionally given oral administration of Shenshuaining tablets based on the treatment of the control group. Before and after treatment，Chinese medicine syndrome scores，kidney function and levels of inflammatory factors in the two groups were compared. The clinical effects and the incidence of adverse reactions were evaluated. Results：The total effective rate was 93.33% in the observation group，higher than that of 84.44% in the control group，the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the Chinese medicine syndrome scores in the observation group were lower than those in the control group，the difference being significant(P＜0.05). After treatment，the levels of serum creatinine(SCr)，blood urea nitrogen(BUN)，cystatin C(Cys- C)，24- hour urine protein(24hUP) in the two groups were decreased when compared with those before treatment， and the albumin(Alb) levels were increased(P＜0.05)； SCr， BUN， Cys- C and 24hUP in the observation group were lower than those in the control group， and Alb level was higher(P＜0.05). After treatment， highsensitivity C-reactive protein(hs-CRP)，tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in serum in the two groups were decreased when compared with those before treatment，and the levels of hs-CRP，TNF-α and IL-6 in the observation group were lower than those in the control group， the difference being significant(P＜0.05). The incidence of adverse reactions was 8.89% in the observation group， lower than that of 17.78% in the control group， the difference being significant(P＜0.05). Conclusion： Shenshuaining tablets combined with compound α- ketoacid tablets for CRF can improve clinical effect and kidney function，and decrease Chinese medicine syndrome scores，the incidence of adverse reactions and micro-inflammation status，with high safety.