Abstract：Objective：To observe the effect of Jianpi Bugu tang combined with Jintiange capsules on bone metabolism levels and pain degree of patients with osteoporotic pain. Methods：A total of 104 cases of patients with osteoporotic pain were selected as study subjects and were divided into the observation group and the control group according to the random number table method，with 52 cases in each group. Based on routine intervention，the control group was additionally given Jintiange capsules， and the observation group was additionally given Jianpi Bugu tang combined with Jintiange capsules. Both groups were treated for one month. The clinical effects in the two groups were compared. The changes in Chinese medicine syndrome scores， bone metabolism levels[bone mineral density(BMD)， bone gla protein(BGP)， bone- specific alkaline phosphatase(BALP)，parathyroid hormone(PTH)，type I collagen annexin carboxy terminal peptide(CTX- 1)] and pain degree [Visual Analogue Scale(VAS)] before and after treatment were compared between the two groups. Results：The total effective rate of clinical effect was 96.15% in the observation group and 78.85% in the control group，the difference being significant(P＜0.05). After treatment， Chinese medicine syndrome scores of low back pain， lower extremity pain and limb burnout in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above three scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment，the values of BMD，BGP，BALP and PTH in the two groups were increased when compared with those before treatment， and the value of CTX- 1 was decreased， differences being significant(P＜0.05)； the values of BMD， BGP， BALP and PTH in the observation group were higher than those in the control group，and the value of CTX- 1 was lower， differences being significant(P＜0.05). After treatment，VAS scores in resting state and active state in the two groups were decreased when compared with those before treatment，and each VAS score in the observation group was lower than that in the control group， differences being significant(P＜0.05). Conclusion： Jianpi Bugu tang combined with Jintiange capsules can obviously improve bone metabolism levels of patients with osteoporotic pain， relieve their clinical symptoms and pain degree and enhance the clinical effect.