Abstract： Objective： To observe the curative effect of Huatan Paizhuo Jiedu method combined with thoracoscopic radical resection for early-stage non-small cell lung cancer and its effect on immune function and quality of life. Methods：A total of 60 cases of patients with non-small cell lung cancer with phlegm-heat obstructing the lung syndrome from stage Ia to stage IIa were selected and divided into the control group and the observation group according to the random number table method，with 30 cases in each group. After thoracoscopic radical resection，the control group was given routine treatment， and the observation group was additionally treated with Chinese medicine of Huatan Paizhuo Jiedu method based on the treatment of the control group. Both groups were treated for three months. The Chinese medicine syndrome scores， the immune function indexes including regulatory T cells(Treg) and T helper 17(Th17) cells， the serum indexes including macrophage inhibitory cytokine- 1(MIC- 1)， urokinase- type plasminogen activator(uPA) and matrix metalloproteinase- 9 (MMP- 9)， the quality of life including Functional Assessment of Cancer Therapy- Lung(FACT- L) scores before and after treatment and the clinical effects in the two groups were compared. During treatment，the incidence of adverse reactions in the two groups was observed. Results：The disease control rate(DCR) was 96.67% in the observation group and 76.67% in the control group，the difference being significant(P＜0.05). After treatment，Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment， and the Chinese medicine syndrome score in the observation group was lower than that in the control group，differences being significant(P＜0.05). After treatment，the Treg values in the two groups were decreased when compared with those before treatment，and the values of Th17 and Th17/ Treg ratio were increased，differences being significant(P＜0.05). After treatment，the Treg value in the observation group was lower than that in the control group，and the values of Th17 and Th17/Treg ratio were higher than those in the control group， differences being significant(P＜0.05). After treatment， the levels of MIC- 1， uPA and MMP- 9 in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above three levels in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the scores of physiological states and emotional states in FACT- L in the two groups were decreased when compared with those before treatment，and the scores of function and related symptoms of lung cancer were increased，differences being significant(P＜ 0.05)；there was no significant difference being found in the comparison of social/family situation before and after treatment (P＞0.05). After treatment，the scores of physiological states and emotional states in FACT-L in the observation group were lower than those in the control group， and the scores of function and related symptoms of lung cancer were higher， differences being significant(P＜0.05)； there was no significant difference being found in the comparison of social/family situation between the two groups(P＞0.05). During treatment，there was no serious adverse reactions related to drugs in the two groups. Conclusion：Huatan Paizhuo Jiedu method combined with thoracoscopic radical resection has a significant clinical effect in treating early-stage non-small cell lung cancer，and can improve clinical symptoms，immune function and quality of life with high medication safety.