Abstract： Objective： To observe the clinical effect of the therapy of Fangji Huangqi tang and modified Wuling powder combined with western medicine on children with nephrotic syndrome of lung- spleen qi deficiency syndrome. Methods：A total of 60 children with nephrotic syndrome were randomly divided into the control group and the observation group according to random number table， with 30 cases in each group. The control group was given prednisone acetate tablets and other conventional western medicine；the observation group was additionally treated with Fangji Huangqi tang and modified Wuling powder based on the treatment of the control group. Both groups were treated for 12 weeks. The indexes of liver and kidney function， including serum albumin(Alb) ， urea nitrogen(BUN) and serum creatinine(Scr) ， the scores of lung- spleen qi deficiency syndrome and clinical effects were compared between the two groups. Results： The total effective rate was 93.33% in the observation group and 66.67% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference in the levels of serum Alb，BUN and SCr between the two groups(P＞0.05). After treatment，the levels of serum Alb in both groups were significantly increased，and the levels of BUN and SCr were significantly decreased(P＜0.05)，and the improvement of the above levels in the observation group was more significant than that in the control group(P＜0.05). Before treatment， there was no significant difference in the scores of lung- spleen qi deficiency syndrome in both groups， such as edema， poor appetite and digestion， pale face， a heavy body and fatigue， shortness of breath and lack of strength，spontaneous sweating，thin and unformed stools，short and insufficient urine(P＞ 0.05). After treatment，the above syndrome scores in both groups were significantly decreased when compared with those before treatment(P＜0.05)， and the above syndrome scores in the observation group were lower than those in the control group(P＜0.05). Conclusion：On the basis of the conventional western medicine，the application of Fangji Huangqi tang and modified Wuling powder has a significant therapeutic effect on the treatment of nephrotic syndrome in children of lung-spleen qi deficiency syndrome，which can obviously improve the kidney function and Chinese medicine syndromes of the children.