Abstract： Objective： To observe the curative effect of Buzhong Yiqi tang combined with western medicine for fatigue in depression of heart-spleen deficiency type. Methods：A total of 60 cases of patients with depression of heart- spleen deficiency type were divided into the control group and the study group according to the random number table method，with 30 cases in each group. The control group was treated with fluoxetine hydrochloride dispersible tablets， and the study group was additionally treated with Buzhong Yiqi tang based on the treatment of the control group. Both groups were treated for four weeks. Before treatment，and after two-week and four-week treatment，the changes in scores of the 17-item Hamilton Depression Rating Scale(HAM- D17) and the Fatigue Scale- 14(FS- 14) in the two groups were compared. During treatment， the incidence of adverse reactions in the two groups were compared. Results： After two- week and four- week treatment， the HAMD17 scores in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05). After fourweek treatment， the HAMD17 score in the study group was lower than that in the control group， the difference being significant(P＜0.05). After two- week and four- week treatment， the scores of physical fatigue and mental fatigue and the total scores of fatigue in the two groups were decreased when compared with those before treatment，differences being significant(P＜0.05). After two-week treatment，the total score of fatigue in the study group was lower than that in the control group，the difference being significant (P＜0.05). After four- week treatment， the score of physical fatigue and the total score of fatigue in the study group were lower than those in the control group， differences being significant(P＜0.05). During treatment， the incidence of adverse reactions was 13.33% in the control group and 6.67% in the study group，there being no significant difference being found in the incidence of adverse reactions between the two groups(P＞0.05). Conclusion： Buzhong Yiqi tang combined with western medicine for fatigue in depression of heart-spleen deficiency type can decrease depressive degree，relieve fatigue，and enhance the clinical effect of western medicine，whose synergistic effect has significant time course features.