Abstract：Objective：To observe the clinical effect of the therapy of Zhibai Dihuang pills combined with conventional western medicine on acute gingivitis. Methods： A total of 80 patients with acute gingivitis were selected and divided into the control group and the observation group according to random number table， with 40 cases in each group. The control group was treated with conventional western medicine， and the observation group was additionally treated with Zhibai Dihuang pills based on the treatment of the control group. The clinical effects in the two groups were evaluated，and the levels of inflammatory factors and pain were detected before and after treatment. Results： The total effective rate was 95.0% in the observation group， higher than that of 75.0% in the control group， the difference being significant(P＜ 0.05). After treatment， the levels of tumor necrosis factor- α(TNF- α)， C- reactive protein(CRP) and interleukin- 8(IL- 8) in serum in the two groups were decreased when compared with those before treatment，and the levels of TNF-α，CRP and IL-8 in the observation group were lower than those in the control group，the difference being significant(P＜0.05). After two weeks and four weeks of treatment，the painless rates in the observation group were higher than those in the control group，the difference being significant(P＜0.05). Conclusion：The therapy of Zhibai Dihuang pills combined with conventional western medicine has a significant clinical effect on the treatment of acute gingivitis， which can reduce inflammatory responses and lessen pain.