Abstract： Objective： To observe the clinical effect of modified Duhuo Jisheng tang combined with percutaneous endoscopic lumbar discectomy for lumbar disc herniation. Methods： A total of 90 cases of patients with lumbar disc herniation were selected retrospectively，and divided into the control group and the observation group according to different treatment methods，with 45 cases in each group. The control group was treated with percutaneous endoscopic lumbar discectomy， and the observation group was additionally treated with Duhuo Jisheng tang based on the treatment of the control group. The clinical effects in the two groups were evaluated. Before and after treatment， the scores of Chinese medicine syndromes， Visual Analogue Scale(VAS)， Oswestry disability index(ODI) and Japanese Orthopaedic Association(JOA)，and the levels of high-sensitivity C-reactive protein(hs-CRP)，tumor necrosis factor-α (TNF- α)，interleukin- 6(IL- 6) and interleukin- 35(IL- 35) in serum in the two groups were compared. The incidence of postoperative complications and the recurrence after treatment were observed. Results：The total effective rate was 97.8% in the observation group，higher than that of 80.0% in the control group(P＜ 0.05). After treatment， the scores of soreness and weakness of waist and knees， lower limb radiation pain，paravertebral tenderness and limb numbness in the two groups were decreased when compared with those before treatment，and the above scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the scores of VAS and ODI in the two groups were decreased when compared with those before treatment，and the scores of VAS and ODI in the observation group were lower than those in the control group(P＜0.05). After treatment， the JOA scores in the two groups were increased when compared with those before treatment，and the JOA score in the observation group was higher than that in the control group(P＜0.05). After treatment，the levels of hs-CRP，TNF-α and IL-6 in serum in the observation group were decreased when compared with those before treatment，and were lower than those in the control group(P＜0.05)；the IL-35 level in serum in the observation group was increased when compared with that before treatment，and higher than that in the control group(P＜0.05). After treatment， the recurrence rate was 2.2% in the observation group， lower than that of 8.9% in the control group， the difference being significant(P＜0.05). Conclusion： Modified Duhuo Jisheng tang combined with percutaneous endoscopic lumbar discectomy has a good curative effect in treating lumbar disc herniation，and can relieve the symptom of low back pain，improve lumbar function and reduce recurrence rate.