Abstract： Objective： To observe the effect of the therapy of Huayu Tongmai tang combined with western medicine on endothelial function and oxidative stress in patients with hypertension. Methods： A total of 164 patients with hypertension were selected and divided into the control group and the treatment group according to the random number table method，with 82 cases in each group. The control group was treated with western medicine，and the treatment group was additionally treated with Huayu Tongmai tang based on the treatment of the control group. Before and after treatment， the changes of levels of blood pressure，24- hour systolic blood standard pressure(24 h SSD) and 24- hour diastolic blood pressure(24 h DSD) were compared between the two groups. The changes of levels of catalase(CAT)， glutathione peroxidase(GSH- PX)， advanced oxidation protein product(AOPP)， interleukin- 17(IL- 17)， homocysteine (Hcy)， angiotensin II(AngII)， endothelin- 1(ET- 1)， nitric oxide(NO)， flow- mediated vasodilatation(FMD) and nitroglycerin- mediated dilation(NMD) were compared between the two groups before and after treatment，and the clinical effects in the two groups were observed. Results：After treatment，the levels of systolic blood pressure，diastolic blood pressure，24-hour SSD and 24-hour DSD in both groups were decreased when compared with those before treatment，and the above four levels in the treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment， the levels of CAT and GSH- Px in both groups were increased when compared with those before treatment， and the levels of AOPP were decreased， differences being significant(P＜0.05)； after treatment， the levels of CAT and GSH-Px in the treatment group were higher than those in the control group，and the level of AOPP was lower，differences being significant(P＜0.05). After treatment，the levels of IL-17 and Hcy in the two groups were decreased when compared with those before treatment，and the above two levels in the treatment group were lower than those in the control group， differences being significant(P＜0.05). After treatment，the levels of AngⅡ and ET-1 in both groups were decreased when compared with those before treatment， and the level of NO was increased， differences being significant(P＜0.05)； after treatment， the levels of Ang Ⅱ and ET- 1 in the treatment group were lower than those in the control group，and the level of NO was higher，differences being significant(P＜0.05). After treatment，the levels of FMD and NMD in both groups were increased when compared with those before treatment， and the above two levels in the treatment group were higher than those in the control group， differences being significant(P＜0.05). The total clinical effective rate was 82.93% in the control group and 93.90% in the treatment group， the difference being significant(P＜0.05). Conclusion： The therapy of Huayu Tongmai tang combined with western medicine can improve the clinical effect on blood pressure in patients with hypertension， reduce the damage of oxidative stress， improve the vascular endothelial function， and alleviate the inflammatory responses.