Abstract：Objective：To observe the clinical effect of the therapy of Jianpi Yishen Quyu tang combined with febuxostat on uric acid nephropathy(UAN). Methods：A total of 74 patients with UAN were selected and randomly divided into the control group and the observation group according to the random number table method， with 37 cases in each group. Both groups were treated with drinking water， low purine diet，appropriate exercise，alkaline urine and so on. The control group was treated with oral administration of febuxostat tablets， and the observation group was additionally treated with Jianpi Yishen Quyu tang based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects in the two groups were evaluated. Before and after treatment the changes of serum uric acid(SUA)，serum creatinine(SCr)，estimated glomerular filtration rate(eGFR)，urinary albumin excretion rate(UAER) and 24- hour urinary protein(24 h- UP) in the two groups were compared. Results：The total effective rate was 94.59% in the observation group， higher than that of 78.38% in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of SUA，SCr and eGFR between the two groups(P＞0.05). After treatment，the levels of SUA and SCr in the two groups were decreased when compared with those before treatment，and the above two levels in the observation group were lower than those in the control group(P＜0.05)；the eGFR level in the two groups was increased when compared with that before treatment， and the eGFR level in the observation group was higher than that in the control group(P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of UAER and 24 h-UP between the two groups (P＞0.05). After treatment，the levels of UAER and 24 h-UP in the two groups were decreased when compared with those before treatment，and the above two levels in the observation group were lower than those in the control group(P＜0.05). Conclusion：The therapy of Jianpi Yishen Quyu tang combined with febuxostat has a definite curative effect on patients with UAN， which can effectively protect the kidney function， reduce the level of serum uric acid，and decrease the urinary protein excretion.